{"id":1698,"date":"2016-08-31T20:07:41","date_gmt":"2016-08-31T12:07:41","guid":{"rendered":"http:\/\/edu.secda.info\/wenft\/?p=1698"},"modified":"2017-07-04T15:00:46","modified_gmt":"2017-07-04T07:00:46","slug":"%e6%b5%a9%e9%bc%8e%e5%85%ac%e5%b8%83%e8%ab%96%e6%96%87%e6%91%98%e8%a6%81-%e6%8f%ad%e7%a7%98%e8%a7%a3%e7%9b%b2%e6%95%b8%e6%93%9a","status":"publish","type":"post","link":"https:\/\/edu.secda.info\/wenft\/?p=1698","title":{"rendered":"\u6d69\u9f0e\u516c\u5e03\u8ad6\u6587\u6458\u8981 \u63ed\u79d8\u89e3\u76f2\u6578\u64da"},"content":{"rendered":"<p><span style=\"font-size: 22px;\"><a href=\"http:\/\/www.obipharma.com\/index.aspx?lang=chi&amp;fn=news_content&amp;no=72\">\u6d69\u9f0e\u516c\u5e03\u8ad6\u6587\u6458\u8981 \u63ed\u79d8\u89e3\u76f2\u6578\u64da<\/a><\/span><br \/>\n<a href=\"http:\/\/udn.com\/news\/story\/7241\/1704847\" target=\"_blank\" rel=\"noopener noreferrer\">2016-05-19 09:18 \u7d93\u6fdf\u65e5\u5831 \u8a18\u8005\u9ad8\u884c\u2571\u5373\u6642\u5831\u5c0e<\/a><\/p>\n<p>\u6d69\u9f0e\uff084174\uff09\u516c\u5e03\u8d74\u7f8e\u570b\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u53e3\u982d\u5831\u544a\u7684\u8ad6\u6587\u6458\u8981\uff0c\u5167\u5bb9\u62ab\u9732\u6297\u4e73\u764c\u65b0\u85e5\u7684\u8f03\u5b8c\u6574\u89e3\u76f2\u6578\u64da\u3002\u6d69\u9f0e\u6307\u51fa\uff0c50%\u7684\u5be6\u9a57\u7d44\u60a3\u8005\u7522\u751f Globo H \u7279\u7570IgG \u6297\u9ad4\uff0c\u7522\u751f\u514d\u75ab\u53cd\u61c9\u60a3\u8005\u7684PFS\uff08\u7121\u60e1\u5316\u5b58\u6d3b\u671f\uff09\u548cOS\uff08\u7e3d\u5b58\u6d3b\u671f\uff09\u90fd\u6709\u986f\u8457\u6539\u5584\uff0c\u5728\u79d1\u5b78\u4e0a\u6709\u91cd\u5927\u610f\u7fa9\uff0c\u672a\u4f86\u5c07\u4f7f\u7528\u9019\u4e9b\u6b21\u65cf\u7fa4\u5206\u6790\u6578\u64da\uff0c\u8a2d\u8a08\u660e\u78ba\u7684\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>\u6d69\u9f0e\u516c\u5e03\u6709\u95dcOPT-822\u6297\u4e73\u764c\u65b0\u85e5\u7684\u8ad6\u6587\u6458\u8981\u5982\u4e0b\uff1a<\/p>\n<p>\u65b9\u6cd5\uff1a \u5728\u6b64\u591a\u570b\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u4e8c\/\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\uff08NCT01516307) \u4e2d\uff0c\u7d93\u904e\u81f3\u5c11\u4e00\u7a2e\u6297\u764c\u7642\u7a0b\u6cbb\u7642\u5f8c\uff0c\u6709\u6700\u591a2\u6b21\u75be\u75c5\u60e1\u5316 (PD) \u4ee5\u53ca\u9054\u5230\u75be\u75c5\u7a69\u5b9a (SD) \u7684\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\uff0c\u4ee52:1\u7684\u6bd4\u4f8b\uff0c\u5728\u7b2c 1\u30012\u30013\u30015\u30019\u300113\u300117\u300125 \u548c 37 \u5468\uff0c\u76ae\u4e0b\u6ce8\u5c04 OPT-822 (30 \u03bcg Globo H)\/OPT-821 (100 \u03bcg) \u6216\u5c0d\u7167\u5291 (PBS) \u53ca\u4f4e\u5291\u91cf\u74b0\u78f7\u91af\u80fa (cyclophosphamide) (300 mg\/m2) \u6cbb\u7642\uff0c\u76f4\u5230\u75be\u75c5\u60e1\u5316(PD)\u6216\u6253\u5b8c9\u91dd\u3002\u53ef\u540c\u6642\u7d66\u4e88\u8377\u723e\u8499\u7642\u6cd5\u3002\u4e3b\u8981\u548c\u6b21\u8981\u7642\u6548\u6307\u6a19\u5206\u5225\u70ba\u7121\u60e1\u5316\u5b58\u6d3b\u671f (PFS) \u548c\u7e3d\u5b58\u6d3b\u671f (OS)\u3002<\/p>\n<p>\u7d50\u679c\uff1a\u5171\u6709349\u540d\u60a3\u8005\u53c3\u8207\u96a8\u6a5f\u5206\u7d44\u8a66\u9a57\uff0c\u5176\u4e2d 348 \u4f8b\u60a3\u8005\u63a5\u53d7\u7814\u7a76\u85e5\u7269\u6216\u5b89\u6170\u5291\u6cbb\u7642\u3014\u610f\u5716\u6cbb\u7642 (ITT)\u3015\uff0c168 \u4f8b\u60a3\u8005 (48%) \u5b8c\u6210 9 \u6b21\u6ce8\u5c04\u7642\u7a0b\u300270% \u70ba\u8377\u723e\u8499\u53d7\u9ad4\u967d\u6027\u4e73\u764c\u60a3\u8005\u300213% \u70ba\u4e09\u9670\u6027\u4e73\u764c\u60a3\u8005\u300262% \u60a3\u8005\u63a5\u53d7\u8377\u723e\u8499\u6cbb\u7642\u3002\u672c\u8a66\u9a57\u7d50\u679c\u672a\u89c0\u5bdf\u5230\u7121\u60e1\u5316\u5b58\u6d3b\u671f(PFS)\u9054\u5230\u7d71\u8a08\u986f\u8457\u5dee\u7570(HR = 0.96 [95% CI 0.74-1.25]\uff0c<span style=\"color: #ff0000;\">p= 0.77<\/span>)\uff0c\u7e3d\u5b58\u6d3b\u671f(OS)\u7684\u671f\u4e2d\u5206\u6790(Interim OS)\u4ea6\u672a\u9054\u986f\u8457\u5dee\u7570(HR = 0.79 [95% CI 0.51-1.22]\uff0c<span style=\"color: #ff0000;\">p = 0.29<\/span>)\u3002\u4f46\u662f\uff0c\u670950%\u7684\u5be6\u9a57\u7d44\u60a3\u8005\uff0c\u5c0d OPT-822\/OPT-821 \u7522\u751f Globo H \u7279\u7570IgG \u6297\u9ad4 (\u9019\u662f\u6307\u6297\u9ad4\u6548\u50f9\u66fe\u5728\u6cbb\u7642\u671f\u9593\u5167\u9054\u5230 \u2265 1:160)\u3002\u9019\u4e9b\u7522\u751f\u514d\u75ab\u53cd\u61c9\u7684\u60a3\u8005\uff0c\u7576\u8207\u5c0d\u7167\u7d44\u6bd4\u8f03\uff0c\u6709\u4ee5\u4e0b\u7d50\u679c: PFS\uff0cHR = 0.71 [95%CI 0.52-0.97]\uff0c<span style=\"color: #ff0000;\">p= 0.029<\/span>\uff1bOS\uff0cHR=0.57 [95%CI 0.33-0.97]\uff0c<span style=\"color: #ff0000;\">p = 0.04<\/span>\uff1b\u7522\u751f\u514d\u75ab\u53cd\u61c9\u7684\u60a3\u8005\uff0c\u548c\u7121\u514d\u75ab\u53cd\u61c9\u60a3\u8005\u6bd4\u8f03\uff0c\u6709\u4ee5\u4e0b\u7d50\u679c: PFS\uff0cHR = 0.52 [95%CI 0.37-0.71]\uff0c<span style=\"color: #ff0000;\">p&lt; 0.0001<\/span>\uff1bOS\uff0cHR = 0.52 [95%CI 0.29-0.92]\uff0c<span style=\"color: #ff0000;\">p= 0.025<\/span>\uff08\u7d50\u679c\u7d93\u57fa\u790e\u75be\u75c5\u72c0\u614b\/\u8377\u723e\u8499\u7642\u6cd5\u4f7f\u7528\u60c5\u6cc1\u6821\u6b63)\u3002\u9019\u5169\u500b\u7d50\u679c\u986f\u793a\uff0c\u7522\u751f\u514d\u75ab\u53cd\u61c9\u60a3\u8005\u7684PFS \u548cOS\u90fd\u6709\u986f\u8457\u6539\u5584\u3002\u7d93\u6642\u9593\u76f8\u4f9dCox \u5206\u6790\u4e26\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\u4e4b\u5f8c\uff0c\u5c0d\u65bc\u5b8c\u6210 9 \u6b21OPT\u6ce8\u5c04\u7642\u7a0b\u8005\uff0c\u5176PFS\u4e5f\u6709\u6539\u5584\u8da8\u52e2(HR = 0.66 [95% CI 0.42-1.01]\uff0c<span style=\"color: #ff0000;\">P = 0.057<\/span>)\u3002\u6574\u9ad4\u800c\u8a00\uff0cOPT-822\/OPT-821 \u8010\u53d7\u6027\u826f\u597d\uff1b\u6700\u5e38\u898b\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba 1\u30012 \u7d1a\u7684\u6ce8\u5c04\u90e8\u4f4d\u76ae\u819a\u53cd\u61c9\u3002<\/p>\n<p>\u7d50\u8ad6\uff1a \u672c\u81e8\u5e8a\u8a66\u9a57PFS\u96d6<span style=\"color: #ff0000;\">\u672a\u9054\u5230\u7d71\u8a08\u986f\u8457\u5dee\u7570<\/span>\uff0c\u7136\u800c\uff0c\u5c0d\u65bc\u6709\u7522\u751f\u514d\u75ab\u53cd\u61c9\u60a3\u8005\u7684PFS \u548cInterim OS\u5747\u6709\u986f\u8457\u6539\u5584\u3002\u672a\u4f86\u5c07\u4f7f\u7528\u9019\u4e9b\u6b21\u65cf\u7fa4\u5206\u6790\u6578\u64da\uff0c\u8a2d\u8a08\u660e\u78ba\u7684\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>new address<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6d69\u9f0e\u516c\u5e03\u8ad6\u6587\u6458\u8981 \u63ed\u79d8\u89e3\u76f2\u6578\u64da 2016-05-19 09:18 \u7d93\u6fdf\u65e5\u5831 \u8a18\u8005<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0},"categories":[6,3],"tags":[],"_links":{"self":[{"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/posts\/1698"}],"collection":[{"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1698"}],"version-history":[{"count":6,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/posts\/1698\/revisions"}],"predecessor-version":[{"id":1766,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=\/wp\/v2\/posts\/1698\/revisions\/1766"}],"wp:attachment":[{"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/edu.secda.info\/wenft\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}